The award-winning filmmaker spoke about the prospect, stating: “I will give it consideration.”
Lee told Entertainment Weekly: “I have nothing against Marvel. I grew up reading Spider-Man comic books.”
The 63-year-old did, however, add that he thought “DC Comics was always corny. I’m just saying. I was all about Marvel”.
While there are not yet any plans for Lee to take on a Marvel film, Lee said: “If the right opportunity comes across. I’m not campaigning for it but I will give it consideration.”
Earlier this month, Lee’s well-received film Da 5 Bloods missed out on a Golden Globe nomination.
The snub was one of many controversial decisions in this year’s line-up, with many film critics and fans also condemning the absence of Michaela Coel’s critically acclaimed BBC series I May Destroy You.
Da 5 Bloods debuted in June last year to positive reviews from both critics and fans. The film is Lee’s first Netflix venture.
You can read The Independent’s three-star review of the movie here.